IBS Develops 'Molecular Editing' Technology to Freely Redesign Complex Drugs

1. A research team at the Institute for Basic Science has developed a 'nitrogen atom transposition' synthesis method that moves the nitrogen atom in pyridine to a desired position.
2. Led by acting director Hong Seung-woo, the team's work achieved an isomer synthesis yield of 88%, maintained at 74% even at a 10-millimole scale.
3. Applied to marketed drugs such as the anticancer drug bismodegib, it produced new candidate molecules, and the team plans to extend it to other nitrogen rings.

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